Weight Management & Body Composition
- Supports reduction of visceral fat, body weight, and waist circumference in generally healthy but overweight adults.
- Supports a healthy body composition and fat loss.
- Supports healthy weight management.
Self-affirmed GRAS · 4 human clinical trials
Pep19 RMH
Advancing Metabolic Health
To Better Lives
A 10 mg daily oral peptide capsule that activates a “browning-like” effect in white fat tissue, supports insulin sensitivity, and improves sleep quality — clinically validated, without acting on the central nervous system.
17%
Visceral fat reduction
6%
HbA1c reduction
14%
Abdominal skinfold
10 mg
Daily oral capsule
Clinically validated benefits
Measurable metabolic
improvements.
01
Reduces visceral fat
Targets adipose tissue directly for measurable fat reduction around the organs.
02
Improves insulin sensitivity
Supports the relationship between circulating insulin and peripheral insulin sensitivity.
03
Preserves lean mass
Maintains muscle tissue while reducing fat — no lean mass loss observed in trials.
04
Peripheral mechanism
Acts on CB1 receptors in white adipose tissue. Does not cross the blood-brain barrier.
05
Supports healthy sleep
Addresses sleep quality and occasional sleeplessness in generally healthy adults.
06
Healthy blood pressure
Supports healthy blood pressure already within the normal range.
The novel science
A 10-amino-acid peptide that
remodels fat tissue from within.
At the cellular level, PEP19 modulates the peripheral CB1 cannabinoid receptor (CB1R) in white adipose tissue. This triggers UCP1 activation and thermogenesis — converting stored white fat into heat — while improving insulin resistance and cardiovascular markers, all independent of weight loss and without crossing the blood-brain barrier.
Peripheral CB1R modulation
Targets receptors in adipose tissue — no CNS activity, no behavioral changes required.
UCP1 thermogenesis
Activates the browning-like conversion of white fat to metabolically active tissue.
Self-affirmed GRAS
Regulatory process led by Corey Hilmas, MD, PhD of KGK Science. Global patent pipeline through 2033.
✓ Neurological safety — does not cross the BBB
✓ No lean muscle mass loss
✓ No gastrointestinal distress
✓ Non-toxic & non-allergenic in studies
Product applications
Regulatory approvals and
acknowledged claims.
Vascular Health
- Supports healthy blood pressure already within the normal range.
Sleep Quality
- Supports sleep quality in generally healthy adults who self-report sleep difficulty.
- Addresses sleep quality and helps with occasional sleeplessness.
Metabolic Health & Diabetes Research
- Supports the relationship between circulating insulin and peripheral insulin sensitivity.
- Evaluated for impact on plasma biomarkers such as glucose and insulin levels.
Scientific publications
Peer-reviewed, independently
published.
- 2025
Pep19: A Novel Approach for Reducing Visceral Fat and Improving Sleep Quality in Obese Adults — Results From an Early-Stage Clinical Trial
Diabetes/Metabolism Research and Reviews (Wiley)
View → - 2024
Safety of white adipose tissue activator cyclophilin A intracellular peptide (Pep19™) in healthy dogs
The Veterinary Journal (Elsevier)
View → - 2022
Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice
International Journal of Molecular Sciences (MDPI)
View → - 2017
A novel peptide that improves metabolic parameters without adverse central nervous system effects
Scientific Reports (Nature Publishing Group)
View →
FAQ
Questions, answered.
Start with Pep19 RMH.
A daily peptide for healthy weight, sleep, and recovery. Manufactured to pharmaceutical-grade purity.